Cell membrane fatty acids influencefundamental properties of the plasma membrane, including membranefluidity, protein functionality, and lipid raft signalling.
Thefatty acid composition of T cell membrane lipids has been widely reported toinfluence immune and inflammatory responses. Evidence suggests thatdietary n-3 PUFA maytarget the plasma membraneof immune cells by altering plasma membrane lipid dynamics, thereby regulating theattenuation of immune cell activation andsuppression of inflammation.
Aslipid-based immunotherapy might be a promising new clinical strategy for thetreatment of inflammatory disorders, Fan YY and coworkers conducted in vitroand in vivo experiments to examine the effects of n-3PUFA on CD4+ T cell membrane order,mitochondrial bioenergetics and lymphoproliferation (Fan YY et al., 2018).
Theirinteresting results demonstrate that the dynamic reshaping of human CD4+ T cell plasma membraneorganisation by n-3 PUFAmay modulate down-stream clonal expansion.
Remembrane’sunique know-how in shaping membrane lipidomics of cultured cells by tailoredlipid supplements is now a must-use in immunotherapy applications and cansignificantly help companies in the development of more effective ATMPs and ofmore efficient production processes.