Physiological perinatal MSCs
This Refeed recreates in vitro a membrane network closely mimicking membrane content and properties of in-vivo Perinatal Mesenchymal Stem Cells. See Chatgilialoglu A. et al., 2017; Cavallini et al., 2018; Pizzuti et al., 2022 for data and further information.
This Refeed recreates in vitro a membrane network closely mimicking membrane content and properties of in-vivo leukocytes. Optimized for Jurkat, Raji, THP-1, suitable also for all the other primary and immortalized leukocyte cells. See Poggi P. et al., 2015 for data and further information.
Advanced Therapy Medicinal Products (ATMPs) are revolutionizing the pharmaceutical sector through the use of sophisticated technologies and personalized treatments. Custom Refeed supplements guarantee the development of more effective ATMPs and of more efficient production processes in the following fields:
- Cell/Gene Regenerative therapies
- Cellular Immunotherapies
- Extracellular Vesicles and Exosomes
Use custom Refeed® to get:
- Desired influence on fundamental cell parameters of interest;
- Better efficiency of in vitro cell manipulation and expansion processes;
- Enhanced clinical efficacy of your Advanced Therapy;
- Fine-tuned immunology according to your necessities;
- Increased yield, potency and properties of EVs/exosomes in GMP processes.
Our scientific pubblications
A tailored lipid supplement restored membrane fatty acid composition and ameliorates in vitro biological features of human amniotic epithelial cells. J Clin Med. 2022.
Restoring in vivo-like membrane lipidomics promotes exosome trophic behavior from human placental mesenchymal stromal/stem cells. Cell Transplant. 2018.
Restored in vivo-like membrane lipidomics positively influence in-vitro features of cultured mesenchymal stromal/stem cells derived from human placenta. Stem Cell Res Ther. 2017.
Membrane fatty acid heterogeneity of leukocyte classes is altered during in-vitro cultivation but can be restored with ad-hoc lipid supplementation. Lipids Health Dis. 2015.